Biochemistry - Biomolecules

Pharm.D. Curriculum

Course Number

PHPS 501

Credits
2

This course lays the biochemical foundation for the understanding of medicinal chemistry, pharmaceutics, pharmacology and pathophysiology. Topics include physical and chemical properties of amino acids, structure and physical properties of proteins, structure and function of hemoglobin, enzyme kinetics, types of inhibitors, and the catalytic triad of chymotrypsin.

This course also covers DNA and RNA function, nucleotide biosynthesis and its regulation in disease, DNA replication, damage, mutation and repair, and transcriptional control of gene expression. Roles of cytochromes P450 as phase I enzymes in the biotransformation of xenobiotics drug and their regulation will also be addressed.