Department of Pharmaceutical Sciences
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Leng Chee Chang, Ph.D.
Assistant Professor
Leng Chee Chang, Ph.D., Assistant Professor. Dr. Chang received her B.S. (Hons.) and M.S. degrees in Chemistry from the National University of Malaysia, and her Ph.D. in Natural Products Chemistry at the University of Illinois at Chicago. Following postdoctoral work at the NIDDK, NIH and at the University of Minnesota at Minneapolis, she accepted a faculty position at the University of Minnesota Duluth, Department of Chemistry and Biochemistry. She has published over 25 papers and four book chapters in her field of scientific interest, natural products research. She is a skilled scientist with a solid devotion to educating students. She has gained teaching experience at the University of Minnesota. As an inaugural member of the department of pharmaceutical sciences, she is on a tenure track.
Email Address: lengchee@hawaii.edu
Research Interest: Natural products
Her research interests are on the isolation, characterization, and biological evaluation of natural products of marine and microbial origin, and she has worked in particular compounds with potential cancer chemotherapeutic, and protein kinase inhibitors. Dr. Chang has been Major and Thesis Advisor for 4 graduate students and has directly supervised 4 postdoctorals and 15 undergraduates.
Bibliography
Publications
Book Chapters
1. Kinghorn, A. D., Chang, L. C., Cui, B. (2001). Bioactive substances from medicinal plants. In: Agrochemical Discovery: Insect, Weed, and Fungal Control, Eds. D. R. Baker and N. Umetsu, Symposium Series No. 774, American Chemical Society Books: Washington, DC, pp. 102-114.
2. Chang, L. C., Kinghorn, A. D. (2001). Flavonoids as cancer chemopreventive agents. In: Bioactive Compounds from Natural Sources: Isolation, Characterisation and Biological Properties. Ed. C. Tringali, Taylor and Francis, London, pp. 161-187.
3. Kinghorn, A. D., Cui, B., Ito, A., Chung, H. S., Seo, E.-K., Long, L., Chang, L. C. (1999). Fractionation of plants to discover substances to combat cancer. In: Biologically Active Natural Products: Pharmaceuticals, Eds. S. J. Cutler and H. G. Cutler, CRC Press, Boca Raton, FL, pp. 17-24.
4. Kinghorn, A. D., Cui, B., Kennelly, E. J., Luyengi, L., Chang, L. C. (1998). Novel plant constituents of biological interest. In: Natural Medicine Research in the 21st Century (Proceedings of the International Symposium on Natural Medicines, Kyoto, Japan, 28-30 October, 1997), Eds. H. Ageta, N. Aimi, Y. Ebizuka, T. Fujita, and G. Honda, Elsevier Science, Amsterdam, pp. 125-135.
Articles
1. Yao, G. M., Chang, L. C. Additional Novel Sulfated Sesterterpene Alkaloids from the Marine Sponge Fasciospongia sp. J. Nat. Prod. 2008. Submitted.
2. Ankudey, F. J., Kiprof, P., Stromquist, E., Chang, L. C. Novel Bioactive Bromotyrosine-Derived Alkaloids from a Marine Sponge Aplysinella sp. Planta Medica. 2007. Accepted.
3. Zhang, H., Skildum, A., Stromquist, E., Hellekant, T. R., Chang, L. C. Bioactive Polybrominated Diphenyl Ethers from the Marine sponge Dysidea sp. J. Nat. Prod. Web release date: January 17, 2008.
4. Yao, G. M., Chang, L. C. Novel Sulfated Sesterterpene Alkaloids from the Marine Sponge Fasciospongia sp. Org. Lett. 2007, 9, 3037-3040.
5. Grüschow, S., Chang, L. C., Mao, Y., Sherman, D. H. Hydroxyquinone O-Methylation in Mitomycin Biosynthesis. J. Am. Chem. Soc. 2007, 129, 6470-6476.
6. Shao, N., Yao, G. M., Chang, L. C. Bioactive Constituents from the Marine Crinoid Himerometra magnipinna. J. Nat. Prod. 2007, 70, 869-871.
7. Barker, L., Lien, B. A., Brun, O., Schaak, D. D., McDonough, K. A., Chang, L. C. A Mycobacterium marinum Zone of Inhibition Assay as a Method for Screening Potential Antimycobacterial Compounds from Marine Extracts. Planta Medica. 2007, 73, 1-5.
8. Yao, G. M., Vidor, N. B., Foss, A. P., Chang, L. C. Lemnalosides A-D: Decalin-Type Bicyclic Diterpene Glycosides from the Marine Soft Coral Lemnalia sp. J. Nat. Prod. 2007, 70, 901-905.
9. Xiang, W., Chang, L. C. Calyculatine: A new dolabellane diterpenoid from the marine sponge Eunicea calyculata. Planta Medica. 2006, 72, 735-739.
10. Kinghorn, A. D., Su, B-N., Jang, D. S., Chang, L. C., Lee, D. H., Gu, J-q., Carcache-Blanco, E., Pawlus, A. D., Lee, S. K., Park, E. J., Cuendet, M., Gills, J. J., Bhat, K., Park, H.-S., Mata-Greenwood, E., Song, L. L., Jang, M., Pezzuto, J. M. Natural inhibitors of carcinogenesis. Planta Medica (Invited review). 2004, 70, 691-705.
11. Chang, L. C., Whittaker, N. F., Bewley, C. A. Crambescidins 826 and dehydrocrambine A: new polycyclic guanidine alkaloids from the marine sponge Monanchora sp. that inhibit HIV-1 fusion. J. Nat. Prod. 2003, 66, 1490-1494.
12. Louis, J. M., Nesheiwat, I., Chang, L. C., Clore, G. M., Bewley, C. A. Covalent Trimers of the Internal N-terminal Trimeric Coiled-Coil of gp41 and antibodies directed against them are potent inhibitors of HIV Envelope-mediated cell fusion. J. Biol. Chem. 2003, 30, 278 (22):20278-85.
13. Su, B.-N., Chang, L. C., Park, E. J., Cuendet, M., Santarsiero, B. D., Mesecar, A. D., Mehta, R. G., Fong, H. H. S., Pezzuto, J. M., Kinghorn, A. D. Bioactive constituents of the seeds of Brucea javanica. Planta Med. 2002, 68, 730-733.
14. Chang, L. C., Otero-Quintero, S., Hooper, J. N. A., Bewley, C. A. Batzelline D and isobatzelline E from the Indopacific sponge Zyzzya fuliginosa. J. Nat. Prod. 2002, 65, 776-778.
15. Kelley, B. S., Chang, L.C., Bewley, C. A. Engineering an obligate domain-swapped dimer of cyanovirin-N with enhanced anti-HIV activity. J. Am. Chem. Soc. 2002, 124, 3210-3211.
16. Chang, L.C., Bewley, C. A. Potent inhibition of HIV-1 fusion by cyanovirin-N requires only a single high affinity carbohydrate binding site: Characterization of low affinity carbohydrate binding site knockout mutants. J. Mol. Biol. 2002, 318, 1-8.
17. Chang, L. C., Otero-Quintero, S., Nicholas, G. M., Bewley, C. A. Phyllolactones A-E: new bishomoscalarane sesterterpenes from the marine sponge Phyllospongia lamellosa. Tetrahedron 2001, 57, 5731-5738.
18. Jeong, H. J., Chang, L. C., Kim, H. K., Kim, I. H., Kinghorn, A. D., Pezzuto, J. M. Aromatase inhibitors from Isodon excisus var. coreanus. Arch. Pharm. Res. 2000, 23, 243-245.
19. Chang, L. C., Gills, J. J., Bhat, K. P. L., Luyengi, L., Farnsworth, N. R., Pezzuto, J. M., Kinghorn, A. D. Activity-guided isolation of constituents of Cerbera manghas with antiproliferative and antiestrogenic activities. Bioorg. Med. Chem. Lett. 2000, 10, 2431-2434.
20. Chang, L. C., Song, L. L., Park, E. J., Luyengi, L., Lee, K.-J., Farnsworth, N. R., Pezzuto, J. M., Kinghorn, A. D. Bioactive constituents of Thuja occidentalis. J. Nat. Prod. 2000, 63, 1235-1238.
21. Chang, L. C., Chávez, D., Gills, J. J., Fong, H. H. S., Pezzuto, J. M., Kinghorn, A. D. Rubiasins A-C, new anthracene derivatives from the roots and stems of Rubia cordifolia. Tetrahedron Lett. 2000, 41, 7157-7162.
22. Chang, L. C., Bhat, K. P. L., Fong, H. H. S., Pezzuto, J. M., Kinghorn, A. D. Novel bioactive steroidal alkaloids from Pachysandra procumbens. Tetrahedron 2000, 56, 3133-3138.
23. Chang, L. C., Chávez, D., Song, L. L., Farnsworth, N. R., Pezzuto, J. M., Kinghorn, A. D. Absolute configuration of novel bioactive flavonoids from Tephrosia purpurea. Org. Lett, 2000, 2, 515-518.
24. Chung, H.-S., Chang, L. C., Lee, S.-K., Shamon, L. A., van Breemen, R. B., Mehta, R. G., Farnsworth, N. R., Pezzuto, J. M., Kinghorn, A. D. Flavonoid constituents of Chorizanthe diffusa with potential cancer chemopreventive activity. J. Agric. Food Chem. 1999, 47, 36-41.
25. Chang, L. C., Bhat, K. P. L., Pisha, E., Kennelly, E. J., Fong, H. H. S., Pezzuto, J. M., Kinghorn, A. D. Activity-guided isolation of steroidal alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens. J. Nat. Prod. 1998, 61, 1257-1262.
26. Chang, L. C., Gerhäuser, C., Song, L. L., Farnsworth, N. R., Pezzuto, J. M., Kinghorn, A. D. Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the Phase II enzyme, quinone reductase. J. Nat. Prod. 1997, 60, 869-873.