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University of Hawaii at Hilo
College of Pharmacy
200 W. Kawili St.
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Dean, College of Pharmacy

CoP Home > Office of the Dean > John M. Pezzuto

Bibliography

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Publications

Articles

201. Gamez, E.J.C., Luyengi, L., Lee, S.K., Zhu, L.-F., Zhou, B.-N., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Antioxidant flavonoid glycosides from Daphniphyllum calycinum. J. Nat. Prod., 61: 706-708, 1998.

202. Pezzuto, J.M., Angerhofer, C.K., and Mehdi, H. Discovery and characterization of natural product drugs. ICAST 98 Proceedings. The 14th International Conference on Advanced Science and Technology, 14: 373-384, 1998.

203. Lee, S.K., Qing, W.G., Mar, W., Luyengi, L., Mehta, R.G., Kawanishi, K., Fong, H.H.S., Beecher, C.W.W., Kinghorn, A.D., and Pezzuto, J.M. Angoline and chelerythrine, benzophenanthridines that do not inhibit protein kinase C. J. Biol. Chem., 273: 19829-19833, 1998.

204. Dharmarathne, H.R.W., Wanigasekara, W.M.A.P., Mata-Greenwood, E., and Pezzuto, J.M. Inhibition of human immunodeficiency virus type I reverse transcriptase activity by cordatolides isolated from Calophyllum cordato-oblongum. Planta Med., 64: 460-461, 1998.

205. Subbaramaiah, K., Chung, W.J., Michaluart, P., Telang, N., Tanabe, T., Inoue, H., Jang, M., Pezzuto, J.M., and Dannenberg, A.J. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J. Biol. Chem., 273: 21875-21882, 1998.

206. Cui, B., Chai, B., Constant, H.L., Santisuk, T., Reutrakul, V., Beecher, C.W.W., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Limonoids from Azadirachta excelsa. Phytochemistry, 47: 1283-1287, 1998.

207. Ito, A., Shamon, L.A., Yu, B., Mata-Greenwood, E., Lee, S.K., van Breemen, R.A., Mehta, R.G., Farnsworth, N.R., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Antimutagenic constituents of Casimiroa edulis with potential cancer chemopreventive activity. J. Agr. Food Chem., 46: 3509-3516, 1998.

208. Chang, L.C., Bhat, K.P.L., Pisha, E., Kennelly, E., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Activity-guided isolation of steroid alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens. J. Nat. Prod., 61: 1257-1262, 1998.

209. El Sayed, K.A., Hamann, M.T., Waddling, C.A., Jensen, C., Lee, S.K., Dunstan, C.A., and Pezzuto, J.M. Structurally novel bioconversion products of the marine natural product sarcophine effectively inhibit JB6 cell transformation. J. Org. Chem., 63: 7449-7455, 1998.

210. Lee, S.K., Cui, B., Mehta, R.R., Kinghorn, A.D., and Pezzuto, J.M. Cytostatic Mechanism and antitumor potential of novel 1H-cyclopenta[b]benzofuran lignans isolated from Aglaia elliptica. Chem.-Biol. Interact., 115: 215-228, 1998.

211. Jang, M. and Pezzuto, J.M. Resveratrol blocks eicosanoid production and chemically-induced cellular transformation: implications for cancer chemoprevention. Pharm. Biol., 36: 28-34, 1998.

212. Cui, B., Chai, H., Santisuk, T., Reutrakul, V., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Novel cytotoxic acylated oligorhamnosides from Mezzettia leptopoda. J. Nat. Prod., 61: 1535-1538, 1998.

213. Poobrasert, O., Constant, H.L., Beecher, C.W.W., Farnsworth, N.R., Kinghorn, A.D., Pezzuto, J.M., Cordell, G.A., Santisuk, T., and Reutrakul, V. Xanthones from the twigs of Mammea siamensis. Phytochemistry, 47: 1661-1663, 1998.

214. Jang, J., and Pezzuto, J.M. Effects of resveratrol on 12-O-tetradecanoylphobol-13-acetate-induced oxidative events and gene expression in mouse skin. Cancer Lett., 134: 81-89, 1998.

215. Qui, S.-X., Sun, H.-D., Lobkovsky, E., Chai, H., Clardy, J., Farnsworth, N.R., Pezzuto, J.M., and Fong, H.H.S. Megathyrin B: a cytotoxic diterpene from Isodon megathyrsus. Planta Med., 64: 728-731, 1998.

216. Kim, D.S., Pezzuto, J.M., and Pisha, E. Synthesis of betulinic acid derivatives with activity against human melanoma. Bioorg. Med. Chem. Lett., 8: 1707-0712, 1998.

217. Yoosook, C., Reutrakul, V., Santisuk, T., Chaichana, S., Pezzuto, J.M., Dong, Y., Clanton, D.J., Kiser, R., and Staley, P. A sensitive assay for anti-HIV-1 drug discovery in a biological safety level-2 laboratory. SE Asian J. Trop. Med. Public Health, 29: 758-762, 1998.

218. Song, L.L., Kosmeder II, J.W., Lee, S.K., Gerhäuser, C., Lantvit, D., Moon, R.C., Moriarty, R.M., and Pezzuto, J.M. Cancer chemopreventive activity mediated by 4'-bromoflavone, a potent inducer of phase II detoxification enzymes. Cancer Res., 59, 578-585, 1999.

219. Angerhofer, C.K., Guinaudeau, H., Wongpanich, V., Pezzuto, J.M., and Cordell, G.A. Antiplasmodial and cytotoxic activity of natural bisbenzylisoquinoline alkaloids. J. Nat. Prod., 62: 59-66, 1999.

220. Chung, H.S., Chang, L.C., Lee, S.K., Shamon, L.A., van Breemen, R.B., Mehta, R.G., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Flavonoid constituents of Chorizanthe diffusa with potential cancer chemopreventive activity. J. Agric. Fd. Chem., 47: 36-41, 1999.

221. Lin, L.-Z., Hu, S.-F., Chu, M., Chan, T.-M., Chai, H., Angerhofer, C.K., Pezzuto, J.M., and Cordell, G.A. Phenolic aporphine-benzylisoquinoline alkaloids from Thalictrum faberi. Phytochemistry, 50: 829-834, 1999.

222. Lee, S.K., Luyengi, L., Mar, W., Gerhäuser, C., Lee, K., Mehta, R.G., Kinghorn, A.D., and Pezzuto, J.M. Inhibitory effect of munetone, an isoflavonoid, on 12-O-tetradecanoylphorbol 13-acetate-induced ornithine decarboxylase activity. Cancer Lett., 136: 59-65, 1999.

223. Chatterjee, P., Pezzuto, J.M., and Kouzi, S.A. Glucosidation of betulinic acid by Cunninghamella species. J. Nat. Prod. 62: 761-763, 1999.

224. Jang, M. and Pezzuto, J.M. Cancer chemopreventive activity of resveratrol. Drugs Exptl. Clin. Res., XXV: 65-77, 1999.

225. Seo, E.-K., Chai, H., Constant, H.L., Santisuk, T., Reutrakul, V., Beecher, C.W.W., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Resveratrol tetramers from Valica diospyroides. J. Org. Chem., 64: 6976-6983, 1999.

226. Alberts, D.S., Colvin, O.M., Conney, A.H., Ernster, V.L., Garber, J.E., Greenwald, P., Gudas, L.J., Hong, W.K., Kelloff, G.J., Kramer, R.A., Lerman, C.E., Mangelsdorf, D.J., Matter, A., Minna, J.D., Nelson, W.G., Pezzuto, J.M., Prendergast, F., Rusch, V.W., Sporn, M.B., Wattenberg, L.W., and Weinstein, B. Prevention of cancer in the next millennium. Report of the Chemoprevention Working Group to the American Association for Cancer Research. Cancer Res., 59: 4743-4758, 1999.

227. Jeong, H.-J., Shin, Y.G., Kim, I.-H., and Pezzuto, J.M. Inhibition of aromatase activity by flavonoids. Arch. Pharmacal Res., 22: 309-312, 1999.

228. Shin, Y.G., Cho, K.H., Chung, S.M., Graham, J., Das Gupta, T.K., Pezzuto, J.M. Determination of betulinic acid in mouse blood, tumor and tissue homogenates by HPLC-electrospray/MS. J. Chromatogr. B, 732: 331-336, 1999.

229. Cui, B., Chai, B., Dong, Y., Horgen, F.D., Hansen, B., Madulid, D.A., Soejarto, D.D., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Quinoline alkaloids from Acronychia laurifolia. Phytochemistry 52: 95-98, 1999.

230. Ito, A., Lee, Y.-H., Chai, H.-B., Gupta, M.P., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. 1',2',3',4'-Tetradehydrotubulosine, a aytotoxic alkaloid from Pogonopus speciosus. J. Nat. Prod., 62: 1346-1348, 1999.

231. Qui, S.-X., Lu, Z.-Z., Luyengi, L., Lee, S.K., Pezzuto, J.M., Farnsworth, N.R., Thompson, L.U., and Fong, H.H.S. Isolation and characterization of flaxseed (Linum usitatissimum) Constituents. Pharm. Biol., 37: 1-7, 1999.

232. Cui, B., Lee, Y.H., Chai, H., Tucker, J.C., Fairchild, C.R., Raventos-Suarez, C., Long, B., Lane, K.E., Menendez, A.T., Beecher, C.W.W., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic sesquiterpenoids from Ratibida columnifera. J. Nat. Prod., 62: 1545-1550,1999.

233. Lee, S.K. and Pezzuto, J.M. Evaluation of the potential of cancer chemopreventive activity mediated by inhibition of 12-O-tetradecanoyl phorbol 13-acetate-induced ornithine decarboxylase activity. Arch. Pharm. Res., 22: 559-564, 1999.

234. Lee, S.K., Song, L., Mata-Greenwood, E., Kelloff, G.J., Steele, V.E., and Pezzuto, J.M. Modulation of in vitro biomarkers of the carcinogenic process by chemopreventive agents. Anticancer Res., 19: 35-44, 1999.

235. Topcu, G., Erenler, R., Cakmak, O., Johansson, C.B., Celik, C., Chai, H.B., and Pezzuto, J.M. Diterpenes from the berries of Juniperus excelsa. Phytochemistry, 50: 1195-1199, 1999.

236. Kinghorn, A.D., Farnsworth, N.R., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., Udeani, G.O., Wani, M.C., Wall, M.E., Navarro, H.A., Kramer, R.A., Menendez, A.T., Fairchild, C.R., Lane, K.E., Forenza, S., Vyas, D.M., Lam, K.S., and Shu, Y.-Z. Novel strategies for the discovery of plant-derived anticancer agents. Pure Appl. Chem., 71: 1611-1618, 1999.

237. Hedayat, A.S., Yan, B., Searle, G.D., and Pezzuto, J.M. Pezzuto. Designs for fitting non-linear dose-response curve. Proc. Biopharm. Sec. Am. Stats. Assoc., 132-137, 1999.

238. Udeani, G.O., Zhao, G.-M., Shin, Y.G., Cooke, B.P., Graham, J. Beecher, C.W.W., Kinghorn, A.D., and Pezzuto, J.M. Pharmacokinetics and tissue distribution of betulinic acid in CD-1 mice. Biopharm. & Drug Disp., 20: 379-383, 1999.

239. Soejarto, D.D., Gyllenhaal, C., Regalado, J.C., Pezzuto, J.M., Fong, H.H.S., Tan, G.T., Xuan, L.T., Bich, T.Q., Southavong, B.H., and O'Neill, M.J. Studies on biodiversity of Vietnam and Laos: a UIC-based ICBG program. Pharm. Biol., 37 (Suppl.): 100-113, 1999.

240. Ulubelen, A., Topçu, G., Chai, H.-B., and Pezzuto, J.M. Cytotoxic activities of diterpenoids isolated from Salvia hypargeia. Pharm. Biol., 37: 148-151, 1999.

241. David, J.P., Santon, A.J., Guedes, M.L., David, J.M., Chai, H.-B., Pezzuto, J.M., Angerhofer, C.K., and Cordell, G.A. Sesquiterpene lactones from Ambrosia artemisiaefolia (Asteraceae). Pharm. Biol., 37: 165-168, 1999.

242. Yang, S.-W., Cordell, G.A., Chai, H.B., Jang, M.S., and Pezzuto, J.M. Cytotoxic activity of some indole derivatives and indole metabolites of Streptomyces staruosporeus. Pharm. Biol., 37: 67-70, 1999.

243. Shin, Y.G., Cordell, G.A., Dong, Y., Pezzuto, J.M., Venkata, A., Rao, N.A., Ramesh, M., Kumar, B.R., and Radhakishan, M. Rapid identification of cytotoxic alkenyl catechols in Semecarpus anacardium using bioassay-linked HPLC-electrospray/MS analysis. Pytochem. Anal., 10: 208-212, 1999.

244. Fong, H.H.S., Kosmeder, J.W., Farnsworth, N.R., Soejarto, D.D., Kinghorn, A.D., and Pezzuto, J.M. Edible plants as sources of cancer chemopreventive agents. Intl. Forum Trad. Med. Proc., October 16-17, 1999: 63-72.

245. Chang, L.C., Chávez, D., Song, L.L., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Absolute configuration of novel bioactive flavonoids from Tephrosia purpurea. Org. Lett., 2: 515-518, 2000.

246. Adeniyi, B.A., Fong, H.H., Pezzuto, J.M., Luyengi, L., and Odelola, H.A. Antibacterial activity of diospyrin, isodiospyrin and bisisodiospyrin from the root of Diospyros piscatoria. Phytother. Res., 14: 112-117, 2000.

247. Peraza-Sánchez, S.R., Chávez, D., Chai, H.-B., Shin, Y.G., García, R., Mejía, M., Fairchild, C.R., Lane, K.E., Menendez, A.T., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic constituents of the roots of Ekmanianthe longiflora. J. Nat. Prod., 63: 492-495, 2000.

248. Seo, E.-K., Chai, H.-B., Chagwedera, T.E., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. 5-(4-Hydroxyphenethenyl)-4,7-dime-thoxycoumarin, a new constituent of Monotes engleri. Planta Med., 66: 182-184, 2000.

249. Tan, G.T., Angerhofer, C.K., and Pezzuto, J.M. Assays useful for the discovery and characterization of natural product drugs. Adv. Nat. Sci., 12: 39-56, 2000.

250. Chang, L.C., Bhat, K.P.L., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Novel bioactive steroid alkaloids from Pachysandra procumbens. Tetrahedron, 56: 3133-3138, 2000.

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