Dean, College of Pharmacy
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Bibliography
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Articles
1. Pezzuto, J.M., Lea, M.A., and Yang, C.S. Binding of metabolically activated benzo(a)pyrene to nuclear macromolecules. Cancer Res. 36: 3647-3653, 1976.
2. Pezzuto, J.M., Lea, M.A., and Yang, C.S. The role of microsomes and the nuclear envelope in the metabolic activation of benzo(a)pyrene leading to binding with nuclear macromolecules. Cancer Res. 37: 3427-3433, 1977.
3. Pezzuto, J.M., Lea, M.A., and Yang, C.S. Binding of metabolically activated benzo(a)pyrene to DNA and histones of rat liver, lung, and regenerating liver. Life Sci. 22: 105-110, 1978.
4. Pezzuto, J.M., Yang, C.S., Yang, S.K., McCourt, D.W., and Gelboin, H.V. Metabolism of benzo(a)pyrene and (-)trans-7,8¬-dihydroxy-7,8-dihydrobenzo(a)pyrene by rat liver nuclei and microsomes. Cancer Res. 38: 1241-1245, 1978.
5. Alford, B.L., Pezzuto, J.M., Tan, K.H., and Hecht, S.M. Both positional isomers of aminoacyl-tRNA's are bound by elongation factor Tu. J. Biol. Chem. 254: 6894-6903, 1979.
6. Pezzuto, J.M. and Hecht, S.M. Amino acid substitutions in protein biosynthesis. Poly A-directed polyphenylalanine synthesis. J. Biol. Chem. 255: 865-869, 1980.
7. Pezzuto, J.M., Lau, P.P., Luh, Y., Moore, P.D., Wogan, G.N., and Hecht, S.M. There is a correlation between the DNA affinity and mutagenicity of several 3-amino-l-methyl-5H-¬pyrido(4,3-b)indoles. Proc. Natl. Acad. Sci. USA 77: 1427-1431, 1980.
8. Pezzuto, J.M., Moore, P.D., and Hecht, S.M. Metabolic activation of 3-amino-l-methyl-5H-pyrido(4,3-b)indole and several structurally related mutagens. Biochemistry 20: 298-305, 1981.
9. Pezzuto, J.M., Antosiak, S.K., Messmer, W.M., Slaytor, M.B., and Honig, G.R. Interaction of the antileukemic alkaloid, 2-¬hydroxy-3,8,9-trimethoxy-5-methylbenzo(c)phenanthridine (Fagaronine), with nucleic acids. Chem.-Biol. Interactions 43: 323-339, 1983.
10. McPherson, D.D. and Pezzuto, J.M. Interaction of 9-aminoacridine, ethidium bromide and harman with DNA characterized by size exclusion high-performance liquid chromatography. J. Chromatogr. 281: 348-354, 1983.
11. McPherson, D.D., Cordell, G.A., Soejarto, D.D., Pezzuto, J.M., and Fong, H.H.S. New peltogynoids and homoisoflavonoids from Caesalpinia pulcherrima. Phytochemistry 22: 2835-2838, 1983.
12. Marcelle, G.B., Ahmed, M.S., Pezzuto, J.M., Cordell, G.A., Waller, D.P., Soejarto, D.D., and Fong, H.H.S. Quantitative analysis of gossypol and gossypol-acetic acid by high-performance liquid chromatography. J. Pharm. Sci. 73: 396-398, 1984.
13. Arisawa, M., Pezzuto, J.M., Kinghorn, A.D., Cordell, G.A., and Farnsworth, N.R. Plant anticancer agents. XXX. Cucurbitacins from Ipomopsis aggregata (Polemoniaceae). J. Pharm. Sci. 73: 411-¬413, 1984.
14. Arisawa, M., Funayama, S., Pezzuto, J.M., Kinghorn, A.D., Cordell, G.A., and Farnsworth, N.R. Potential anticancer agents. XXXII. Hydroquinone from Ipomopsis aggregata (Polemoniaceae). J. Nat. Prod. 47: 393-394, 1984.
15. Arisawa, M., Pezzuto, J.M., Bevelle, C., and Cordell, G.A. Potential anticancer agents. XXXI. N-demethylation of fagaronine. J. Nat. Prod. 47: 453-458, 1984.
16. Fang, X., Phoebe, Jr., C.H., Pezzuto, J.M., Fong, H.H.S., Farnsworth, N.R., Yellin, B., and Hecht, S.M. Plant antitumor agents. XXXIV. Cucurbitacins from Elaeocarpus dilichostylus. J. Nat. Prod. 47: 988-993, 1984.
17. Guo, J.-X., Handa, S.S., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Plant anticancer agents. XXXIII. Constituents of Passerina vulgaris. Planta Med. 50: 264-265, 1984.
18. Pezzuto, J.M., Swanson, S.M., and Farnsworth, N.R. Evaluation of the mutagenic potential of Endod (Phytolacca dodecandra), a molluscicide of potential value for the control of schistosomiasis. Toxicol. Lett. 22: 15-20, 1984.
19. Compadre, C.M., Pezzuto, J.M., Kinghorn, A.D., and Kamath, S.K. Hernandulcin: an intensely sweet compound discovered by review of ancient literature. Science 227: 417-419, 1985.
20. Ratko, T.A. and Pezzuto, J.M. An improved fluorometric method for quantitative high-performance liquid chromatographic analysis of methylated guanine in DNA. J. Chromatogr. 324: 484-488, 1985.
21. Pezzuto, J.M., Compadre, C.M., Swanson, S.M., Nanayakkara, N.P.D., and Kinghorn, A.D. Metabolically activated steviol, the aglycone of stevioside, is mutagenic. Proc. Natl. Acad. Sci. USA 82: 2478-2482, 1985.
22. Wong, S.M., Pezzuto, J.M., Fong, H.H.S., and Farnsworth, N.R. Isolation, structure elucidation and chemical synthesis of 2-¬hydroxy-3-octadecyl-5-methoxy-1,4-benzoquinone (Irisoquin), a cytotoxic constituent of Iris missouriensis. J. Pharm. Sci. 74: 1114-1116, 1985.
23. Fiebig, M., Duh, C.-Y., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Plant anticancer agents. XLI. Cardiac glycosides from Streblus asper. J. Nat. Prod. 48: 981-985, 1985.
24. Fiebig, M., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Koenoline, A further cytotoxic carbazole alkaloid from Murraya koenigii. Phytochemistry 24: 3041-3043, 1985.
25. Fang, X., Nanayakkara, N.P.D., Phoebe, Jr., C.H., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Plant anticancer agents. XXXVII. Constituents of Amanoa oblongifolia. Planta Med., 346-347, 1985.
26. Pezzuto, J.M., Nanayakkara, N.P.D., Compadre, C.M., Swanson, S.M., Kinghorn, A.D., Guenthner, T.M., Sparnins, V.L., and Lam, L.K.T. Characterization of bacterial mutagenicity mediated by 13-hydroxy-ent-kaurenoic acid (Steviol) and several structurally-related derivatives and evaluation of potential to induce glutathione S-transferase in mice. Mutation Res. 169: 93-103, 1986.
27. McPherson, D.D., Che, C.-T., Cordell, G.A., Soejarto, D.D., Pezzuto, J.M., and Fong, H.H.S. Diterpenoids from Caesalpinia pulcherrima. Phytochemistry 25: 167-170, 1986.
28. Wong, S.-M., Oshima, Y., Pezzuto, J.M., Fong, H.H.S., and Farnsworth, N.R. Plant anticancer agents. XXXIX. Triterpenes from Iris missouriensis (Iradaceae). J. Pharm. Sci. 75: 317-320, 1986.
29. Wong, S.-M., Pezzuto, J.M., Fong, H.H.S. and Farnsworth, N.R. Isolation and characterization of a new triterpene from Iris missouriensis. J. Nat. Prod. 49: 330-333, 1986.
30. Duh, C.-Y., Phoebe, Jr., C.H., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Plant anticancer agents. XLII. Cytotoxic constituents from Wikstroemia elliptica. J. Nat. Prod. 49: 706-709, 1986.
31. Chang, Y.S., Pezzuto, J.M., Fong, H.H.S., and Farnsworth, N.R. Evaluation of the mutagenic potential of American Ginseng (Panax quinquefolius L.). Planta Med. 338-339, 1986.
32. Hussain, R.A., Kim, J., Hu, T.-W., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Isolation of a highly sweet constituent from Cinnamonum osmophloeium leaves. Planta Med. 403-404, 1986.
33. Choi, Y.-H., Kim, J., Pezzuto, J.M., Kinghorn, A.D., Farnsworth, N.R., Lotter, H., and Wagner, H. Agrostistachin, a novel cytotoxic macrocyclic diterpene from Agrostistachys hookeri. Tetrahedron Lett. 27: 5795-5798, 1986.
34. Braun, R.J., Ratko, T.A., Pezzuto, J.M., and Beattie, C.W. Estrous cycle modification of rat uterine DNA alkylation by N-methyl-N-nitrosourea. Cancer Lett. 37: 345-352, 1987.
35. Duh, C.-Y., Pezzuto, J.M., Kinghorn, A.D., Leung, S.L., and Farnsworth, N.R. Plant anticancer agents. XLIV. Cytotoxic constituents from Stizophyllum riparium. J. Nat. Prod. 50: 63-74, 1987.
36. Wong, S.-M., Konno, C., Oshima, Y., Pezzuto, J.M., Fong, H.H.S., and Farnsworth, N.R. Irisones A and B: two new isoflavones from Iris missouriensis Nutt. (Iridaceae). J. Nat. Prod. 50: 178-¬180, 1987.
37. Nanayakkara, N.P.D., Klocke, J.A., Compadre, C.M., Hussain, R.A., Pezzuto, J.M., and Kinghorn, A.D. Characterization and feeding deterrent effects on the Aphid, Schizaphis graminum, of some derivatives of the sweet compounds, Stevioside and Rebaudioside A. J. Nat. Prod. 50: 434-441, 1987.
38. Compadre, C.M., Hussain, R.A., Lopez de Compadre, R.L., Pezzuto, J.M., and Kinghorn, A.D. The intensely sweet sesquiterpene, Hernandulcin: isolation, synthesis, characterization, and preliminary safety evaluation. J. Agric. Food Chem. 35: 273-279, 1987.
39. Compadre, C.M., Hussain, R.A., Nanayakkara, N.P.D., Pezzuto, J.M., and Kinghorn, A.D. Mass spectral analysis of some derivatives and in vitro metabolites of Steviol, the aglycone of the natural sweeteners, Stevioside, Rebaudioside A, and Rubusoside. Biomed. Environ. Mass Spectrom. 15: 211-222, 1988.
40. Ratko, T.A., Braun, R.J., Pezzuto, J.M., and Beattie, C.W. Estrous cycle modification of rat mammary gland DNA alkylation by N-methyl-N-nitrosourea. Cancer Res. 48: 3090-3093, 1988.
41. Compadre, C.M., Hussain, R.A., Lopez de Compadre, R.L., Pezzuto, J.M., and Kinghorn, A.D. Analysis of structural features responsible for the sweetness of the sesquiterpene, Hernandulcin. Experientia 44: 447-449, 1988.
42. Choi, Y.-H., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Plant anticancer agents. XLVI. Cytotoxic casbene-type constituents of Agrostistachys hookeri. J. Nat. Prod. 51: 110-116, 1988.
43. Liu, S.-Q., Pezzuto, J.M., Kinghorn, A.D., and Scheld, H.W. Additional biologically active constituents of the Chinese Tallow Tree (Sapium sebiferum). J. Nat. Prod. 51: 619-620, 1988.
44. Swanson, S.M., Jiang, J.-X., de Souza, N.J., and Pezzuto, J.M. A rapid and sensitive bioassay involving cultured rat glioma cells to screen for substances capable of elevating intracellular cyclic AMP concentration. J. Nat. Prod. 51: 929-936, 1988.
45. Kim, J., Pezzuto, J.M., Soejarto, D.D., Lang, F.A., and Kinghorn, A.D. Polypodoside A, an intensely sweet constituent of the rhizomes of Polypodium glycyrrhiza. J. Nat. Prod. 51: 1166-1172, 1988.
46. Lam, L.K.T., Garg, P.K., Swanson, S.M., and Pezzuto, J.M. Evaluation of the cytotoxic potential of catechols and quinones structurally-related to butylated hydroxyanisole. J. Pharm. Sci. 77: 393-395, 1988.
47. Nanayakkara, N.P.D., Hussain, R.A., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. An intensely sweet dihydroflavonol derivative based on a natural product lead compound. J. Med. Chem. 31: 1250-1253, 1988.
48. Pezzuto, J.M., Swanson, S.M., Mar, W., Che, C.-T., Cordell, G.A., and Fong, H.H.S. Evaluation of the mutagenic and cytotoxic potential of aristolochic acid (3,4-methylenedioxy-8-methoxy-l0-¬nitrophenanthrene-l-carboxylic acid) and several derivatives. Mutation Res. 206: 447-454, 1988.
49. Pezzuto, J.M., Shieh, H.-L., Shaughnessy, E., and Beattie, C.W. Approaches for drug development in treatment of advanced melanoma. Sem. Oncol. 15: 578-588, 1988.
50. Choi, Y.-H., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Ellagic acid derivatives of Agrostistachys hookeri. Planta Med. 511-513, 1988.