Dean, College of Pharmacy

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Publications

Articles

101. Wickramaratne, D.B.M., Pengsuparp, T., Mar, W., Chai, H.-B., Chagwedera, T.E., Beecher, C.W.W., Farnsworth, N.R., Kinghorn, A.D., Pezzuto, J.M., and Cordell, G.A. Novel antimitotic dibenzocyclo-octadiene lignan constituents of the stem bark of Steganotaenia araliacea. J. Nat. Prod. 56: 2083-2090, 1993.

102. Nshimo, C.M., Pezzuto, J.M., Kinghorn, A.D., and Farnsworth, N.R. Cytotoxic constituents of Muntingia calagura leaves and stems collected in Thailand. Int. J. Pharmacog. 31: 77-81, 1993.

103. Lin, L.-J., Lin, L.-Z, Pezzuto, J.M., Cordell, G.A., and Ruangrungsi, N. Isogambogic acid and isomorellinol from Garcinia hanburyi. Magn. Reson. Chem. 31: 340-347, 1993.

104. Tan, G.T., Wickramasinghe, A., Verma, S., Hughes, S.H., Pezzuto, J.M., Baba, M., and Mohan, P. Sulfonic acid polymers are potent inhibitors of HIV-1 induced cytopathogenicity and the reverse transcriptases of both HIV-1 and HIV-2. Biochim. Biophys. Acta 1181: 183-188, 1993.

105. Topçu, G., Öksüz, S., Shieh, H.-L., Cordell, G.A., Pezzuto, J.M., and Bozok-Johansson, C. Cytotoxic and antibacterial sesquiterpenes from Inula graveolens. Phytochemistry 33: 407-410, 1993.

106. Afifi, M.S.A., Ahmed, M.M., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic flavonolignan and flavones from Verbascum sinaiticum leaves. Phytochemistry 34: 839-841, 1993.

107. Öksüz, S., Shieh, H.-L., Pezzuto, J.M., Özhatay, N., and Cordell, G.A. Biologically active compounds from the Euphorbiaceae. Part 1. Triterpenoids of Euphorphia nicaeensis subsp. glareosa. Planta Med. 59: 472-473, 1993.

108. Gerhäuser, C., Samtleben, R., Tan, G.T., Pezzuto, J.M., Lottspeich, F., and Wagner, H. Peponin, a new ribosome-inactivating protein isolated from seeds of Cucurbita pepo L. inhibits human immunodeficiency virus type I reverse transcriptase. Pharm. Pharmacol. Lett. 3: 71-75, 1993.

109. Dai, J.-R., Chai, H., Tsauri, S., Padmawinata, K., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic constituents of the roots of the Indonesian medicinal plant Fibraurea chloroleuca. Phytother. Res. 7: 290-294, 1993.

110. Alkan-Onyuksel, H., Ramakrishnan, S., Chai, H.-B., and Pezzuto, J.M. A mixed micellar formulation suitable for the parenteral administration of Taxol. Pharm. Res. 11: 206-212, 1994.

111. Wall, M.E., Wani, M.C., Fullas, F., Oswald, J.B., Brown, D.M., Santisuk, T., Reutrakul, V., McPhail, A.T., Farnsworth, N.R., Pezzuto, J.M., Kinghorn, A.D., and Besterman, J.M. Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines. J. Med. Chem. 37: 1465-1470, 1994.

112. Ngassapa, O., Soejarto, D.D., Pezzuto, J.M., and Farnsworth, N.R. Quinone-methide triterpenes and salaspermic acid from Kokoona ochracea. J. Nat. Prod. 57: 1-8, 1994.

113. Pengsuparp, T., Cai, L., Fong, H.H.S., Kinghorn, A.D., Pezzuto, J.M., Wani, M.C., and Wall, M.E. Pentacyclic triterpenes derived from Maprounea africana are potent inhibitors of HIV-1 reverse transcriptase. J. Nat. Prod. 57: 415-418, 1994.

114. Kardono, L.B.S., Tsauri, S., Pezzuto, J.M., Kinghorn, A.D., and Padmawinata, K. Cytotoxic isoflavonoids of Pachyrrhizus erosus seeds. Jurnal Kimia Terapan Indonesia 4: 2-12, 1994.

115. Fullas, F., Hussain, R.A., Chai, H., Pezzuto, J.M., Soejarto, D.D., and Kinghorn, A.D. Cytotoxic constituents of Baccharis gauichaudiana. J. Nat. Prod. 57: 801-807, 1994.

116. Rimando, A.M., Pezzuto, J.M., Farnsworth, N.R., Santisuk, T., Reutrakul, V., and Kawanishi, K. New lignans from Anogeisus acuminata with HIV-1 reverse transcriptase inhibitory activity. J. Nat. Prod. 57: 896-904, 1994.

117. Chen, I.-S., Wu, S.-Y., Tsai, I.-L., Wu, T.-S., Pezzuto, J.M., Lu, M.C., Chai, H., Suh, N., and Teng, C.-M. Chemical and bioactive constituents from Zanthoxylum simulans. J. Nat. Prod. 57: 1206-1211, 1994.

118. Sun, H.-D., Lin, Z.-W., Niu, F.-D., Lin, L.-Z., Angerhofer, C.K., Chai, H.-B., Pezzuto, J.M., and Cordell, G.A. Cytotoxic diterpenoids from Isodon megathyrsus. J. Nat. Prod. 57: 1424-1429, 1994.

119. Lin, L.-Z., Hu, S.-F., Zaw, K., Lin, J., Zheng, D.-M., Angerhofer, C.K., Chai, H.-B., Pezzuto, J.M., and Cordell, G.A. Thalifaberidine, a cytotoxic aporphine-benzylisoquinoline alkaloid from Thalictrum faberi. J. Nat. Prod. 57: 1430-1436, 1994.

120. Rimando, A.M., Pezzuto, J.M., and Farnsworth, N.R. Revision of the NMR assignments of pterostilbene and of dihydrodehydrodiconiferyl alcohol: cytotoxic constituents from Anogeissus acuminata. Nat. Prod. Res. 4: 267-272, 1994.

121. Gören, N., Tahtasakal, E., Gil, R.R., Pezzuto, J.M., Cordell, G.A., Schwarz, B., and Proksch, P. Sesquiterpene lactones from Tanacetum argenteum subsp. argenteum. Phytochemistry 36: 389-392, 1994.

122. Luyengi, L., Lee, I.-S., Mar, W., Fong, H.H.S., Pezzuto, J.M., and Kinghorn, A.D. Rotenoids and chalcones from Mundulea sericea that inhibit phorbol ester-induced ornithine decarboxylase activity. Phytochemistry 36: 1523-1526, 1994.

123. Cordell, G.A., Angerhofer, C.K., and Pezzuto, J.M. Recent studies on cytotoxic, anti-HIV and antimalarial agents from plants. Pure & Appl. Chem. 66: 2283-2286, 1994.

124. Mehta, R.G., Liu, J., Constantinou, A., Hawthorne, M., Pezzuto, J.M., Moon, R.C., and Moriarty, R.M. Structure-activity relationships of brassinin in preventing the development of carcinogen-induced mammary lesions in organ culture. Anticancer Res. 14: 1209-1214, 1994.

125. You, M., Ma, X., Mukherjee, R., Farnsworth, N.R., Cordell, G.A., Kinghorn, A.D., and Pezzuto, J.M. Indole alkaloids from Peschiera laeta that enhance vinblastine-mediated cytotoxicity with multidrug-resistant cells. J. Nat. Prod., 57: 1517-1522, 1994.

126. König, G.M., Wright, A.D., Sticher, O., Angerhofer, C.K., and Pezzuto, J.M. Biological activities of selected marine natural products. Planta Med., 60: 532-537, 1994.

127. Öksüz, S., Gil, R.R., Chai, H., Pezzuto, J.M., Cordell, G.A., and Ulubelen, A. Biologically active compounds from the Euphorbiaceae. Part 2. Triterpenoids for Euphorbia cyparissias. Planta Med., 60: 594-596, 1994.

128. Shamon, L.A., Chen, C., Mehta, R.G., Steele, V., Moon, R.C., and Pezzuto, J.M. A correlative approach for the discovery of antimutagens that demonstrate cancer chemopreventive activity. Anticancer Res., 14: 1775-1778, 1994.

129. Ma, X., Lee, I.-S., Chai, H.-B., Zaw, K., Farnsworth, N.R., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic clerodane diterpenes from Polyalthia barnesii. Phytochemistry, 37: 1659-1662, 1994.

130. Mehta, R.G., Liu, J., Constantinou, A., Thomas, C.F., Hawthorne, M., You, M., Gerhäuser, C., Pezzuto, J.M., Moon, R.C., and Moriarty, R.M. Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage. Carcinogenesis, 16: 399-404, 1995.

131. Sun, H.-D., Lin, Z.-W., Niu, F.D., Lin, L.-Z., Chai, H.B., Pezzuto, J.M., and Cordell, G.A. Cytotoxic ent-kaurene diterpenoids from three Isodon species. Phytochemistry, 38: 437-442, 1995.

132. Lee, I.-S., Ma, X., Chai, H.-B., Madulid, D.A., Lamont, R.B., O'Neill, M.J., Besterman, J.M., Farnsworth, N.R., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Novel cytotoxic labdane diterpenoids for Neouvaria acuminatissima. Tetrahedron, 51: 21-28, 1995.

133. Wickramaratne, D.B.M., Mar, W., Chai, H., Castillo, J.J., Farnsworth, N.R., Soejarto, D.D., Cordell, G.A., Pezzuto, J.M., and Kinghorn, A.D. Cytotoxic constituents of Bursera permollis. Planta Med., 61: 80-81, 1995.

134. Gerhäuser, C., Mar, W., Lee, S.K., Suh, N., Luo, Y., Kosmeder, J., Moriarty, R.M., Luyengi, L., Kinghorn, A.D., Fong, H.H.S., Mehta, R.G., Constantinou, A., Moon, R.C., and Pezzuto, J.M. Rotenoids mediate potent chemopreventive activity through transcriptional regulation of ornithine decarboxylase. Nature Medicine, 1: 260-266, 1995.

135. Suh, N., Luyengi, L., Fong, H.H.S., Kinghorn, A.D., and Pezzuto, J.M. Discovery of natural products as chemopreventive agents utilizing HL-60 cell differentiation as a model. Anticancer Res., 15: 233-240, 1995.

136. Kinghorn, A.D., Farnsworth, N.R., Beecher, C.W.W., Cordell, G.A., Pezzuto, J.M., Wall, M.E., Wani, M.C., Brown, D.M., O'Neill, M.J., Lewis, J.A., Tait, R.M., Besterman, J.M., and Harris, R.J.R. Novel strategies for plant-derived anticancer agents. Int. J. Pharmacog., 33 (Suppl.): 48-58, 1995.

137. Chaudhuri, S.K., Fullas, F., Brown, D.M., Wani, M.C., Wall, M.E., Cai, L., Mar, W., Lee, S.-K., Luo, Y., Zaw, K., Fong, H.H.S., Pezzuto, J.M. and Kinghorn, A.D. Pentacyclic triterpenoids from Maprounea africana as potential antagonists of tumor-promoting phorbol esters. J. Nat. Prod., 58: 1-9, 1995.

138. Falch, B.S., König, G.M., Wright, A.D., Sticher, O., Angerhofer, C.K., and Pezzuto, J.M. and Bachmann, H. Biological activities of cyanobacteria: evaluation of extracts and pure compounds. Planta Med., 61: 11-18, 1995.

139. You, M., Wickramaratne, M., Silva, G.L., Chai, H., Chagwedera, T.E., Farnsworth, N.R., Cordell, G.A., Kinghorn, A.D., and Pezzuto, J.M. (-)-Roemerine, an aporphine alkaloid from Annona Senegalensis that reverses the multiple drug resistance phenotype with cultured cells. J. Nat. Prod., 58: 598-604, 1995.

140. Pengsuparp, T., Cai, L., Constant, H., Fong, H.H.S., Lin, L.-Z., Kinghorn, A.D., Pezzuto, J.M., Cordell, G.A., Ingolfsdottir, K., Wagner, H., and Hughes, S.H. Mechanistic evaluation of new plant-derived compounds that inhibit HIV-1 reverse transcriptase. J. Nat. Prod., 58: 1024-1031, 1995.

141. Silva, G.L., Chai, H., Gupta, M.P., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., Beecher, C.W.W., and Kinghorn, A.D. Cytotoxic biflavonoids from Selaginella willdenowii. Phytochemistry, 40: 129-134, 1995.

142. Gil, R.R., Lin, L.-Z., Chai, H.-B., Pezzuto, J.M., and Cordell, G.A. Cardinolides from Nirerembergia aristata. J. Nat. Prod., 58: 848-856, 1995.

143. Pisha, E., Chai, H., Lee, I.-S., Chagweder, T.E., Farnsworth, N.R., Cordell, G.A., Beecher, C.W.W., Fong, H.H.S., Kinghorn, A.D., Brown, D.M., Wani, M.C., Wall, M.E., Hieken, T.J., Das Gupta, T.K., and Pezzuto, J.M. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nature Medicine, 1: 1046-1051, 1995 (Cover article for issue Number 10, October 1995).

144. Kennelly, E.J., Cai, L., Long, L., Shamon, L., Zaw, K., Zhow, B.-N., Pezzuto, J.M., and Kinghorn, A.D. Novel highly sweet secodammarane glycosides from Pterocarya paliurus. J. Agric. Food Chem., 43: 2602-2607, 1995.

145. Fullas, F., Brown, D.M., Wani, M.C., Wall, M.E., Chagwedera, T.E., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D. Gummiferol, a cytotoxic polyacetylene from the leaves of Adenia gummifera. J. Nat. Prod., 58: 1625-1628, 1995.

146. Swanson, S.M. and Pezzuto, J.M. Enhancement of benzo(a)pyrene metabolism mediated by retinol acetate in cultured human bronchial epithelial cells. Oncol. Rep., 2: 1011-1015, 1995.

147. Lin, L.-Z., Hu, S.-F., Chai, H., Pengsuparp, T., Pezzuto, J.M., Cordell, G.A., Ruangrungsi, N. Lycorine alkaloids from Hymenocallis littoralis. Phytochemistry, 40: 1295-1298, 1995.

148. Gil, R.R., Chai, H.-B., Pezzuto, J.M., and Cordell, G.A. Cardenolides from Nierembergia aristata. J. Nat. Prod., 58: 848-856, 1995.

149. Leaman, D.J., Arnason, J.T., Yusuf, R., Sangat-Roemantyo, H., Soedjito, H., Angerhofer, C.K., and Pezzuto, J.M. Malaria remedies of the Kenyah of the Apau Kayan, East Kalimantan, Indonesian Borneo: a quantitative assessment of local consensus as an indicator of biological efficacy. J. Ethnopharmacol., 49: 1-16, 1995.

150. Öksüz, S., Gürek, F., Gill, R.R., Pengsuparp, T., Pezzuto, J.M., and Cordell, G.A. Four diterpene esters from Euphorbia myrisinites. Phytochemistry, 38: 1457-1462, 1995.

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