Department of Pharmaceutical Sciences

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Aaron Jacobs, Ph.D.
Aaron Jacobs

Associate Professor

My laboratory investigates the role of cell stress in disease processes (e.g. cancer) and responses to drug therapy (e.g. drug resistance, adverse effects). Ongoing project in my lab include: the discovery of HSF1-modulating drugs; the role of c-myc in stress-mediated apoptosis; the role of HSF1 in ECM biosynthesis and fibrosis; and the anti-cancer properties of flavokawains from Kava.


  • B.S., Biology, University of California, Irvine
  • Ph.D., Pharmacology, University of California, Los Angeles
  • Postdoctoral Fellow, Vanderbilt University

Classes and Courses

  • Drug Action I
  • Integrated Therapeutics I-IV
  • Emerging Trends in Drug Discovery
  • Receptor Theory and Signal Transduction

Selected Presentations and/or Publications

  • Anticancer Drugs (2015) 26(6): 657-666
  • Biochemical Pharmacology (2014) 87(3):445-455
  • Molecular and Cellular Biochemistry (2012) 362: 55-63
  • Accounts of Chemical Research, 2010, 43(5):673-683

Active Grants

  • Leahi Fund for Pulmonary Research
  • P20GM103466 Hawaii IDeA Networks of Biomedical Research Excellence (INBRE)

Awards and Honors

  • Excellence in Teaching, 2010, 2012, 2013, 2014, 2015