Department of Pharmaceutical Sciences

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Dana-Lynn T. Koomoa-LangeDana-Lynn T. Koomoa-Lange

Assistant Professor

Dr. Koomoa, Assistant Professor of the Department of Pharmaceutical Sciences, investigates the role of proteins in the malignant progression of cancer, and other pathophysiological processes. Much of her research is focused on providing new insights into neuroblastoma and other types of cancers driven by myc expression (c-myc and N-myc).

Koomoa's lab investigates the role of ion channel proteins and channel regulatory proteins that are often over-expressed or down-regulated in cancer, in tumor progression. Koomoa has shown that these calcium- and magnesium-permeable ion channels, and channel regulatory proteins, play a critical role in regulating neuroblastoma tumor growth, and metastasis, while inhibitors of these proteins inhibit these processes. In addition, Koomoa's lab investigates the role of these proteins in other physiological and pathophysiological processes (e.g. Immune cell function, Central Nervous System disorders). Her projects involve the use of molecular biological, biochemical and biophysical techniques. In addition, multi-plexed assays were established using the Perkin Elmer High-throughput Operetta imaging, live-cell ratio-metric calcium imaging and electrophysiological patch-clamp recordings, in order to correlate results from multiple assays.

Education

  • B.S., Cell and Molecular Biology, San Diego State University (San Diego, CA)
  • Ph.D., Molecular Pharmacology, Physiology and Biotechnology, Brown University (Providence, RI)
  • Postdoctoral Fellow, Laboratory of Cell and Molecular Signaling, Queen's Medical Center/LCMS (Honolulu, HI)
  • Postdoctoral Fellow, Natural Products and Cancer Biology, UH Cancer Center (Honolulu, HI)

Classes and Courses

  • Integrative Therapeutics IV (PHPP 518)
  • Biochemistry (PHPS 752)

Selected Presentations and/or Publications

  • International Journal of Oncol., 2012, accepted
  • Biochem. Pharmacology, 2010, 80(2):170-8
  • Molecular Cancer Therapeutics, 2009, 8(7):2067-75
  • Cancer Research, 2008, 68(23):9825-31
  • Clinical Cancer Research, 2007, 13(21):6312-9
  • Current Biology, 2006, Vol. 16 (20): 2073-9
  • Nature Cell Biology, 2006, Vol. 8(7): 771-3
  • Science, 2006, Vol. 312 (5777): 1220-3

Active Grants

  • K01 , National Cancer Institute (NCI), NIH
  • Young Investigator's Awarde (ALSF)
  • UH CoP start-up Funds

Awards and Honors

  • American Association for Cancer Research Minority Scholar in Cancer Research Award (2011)
  • Fellow, Keystone Symposium on Molecular and Cellular Biology (2009-2010)
  • University of Hawai'i Research Council Fellowship Award (2007 and 2008)
  • Carl Storm Fellowship (2007)
  • Helen F. Cserr Memorial Fellow, Outstanding Academic Achievement (2004-2005)
  • MDIBL Research Fellowship, Mt. Desert Island Biological Laboratory (2003)