Department of Pharmaceutical Sciences

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Daniela Gündisch (Guendisch), Ph.D.
Daniela Gündisch

Associate Professor

Research Interests
Drug development; CNS drugs; radiotracers (PET, SPECT); in silico ADMET; chemistry of drug degradation

Research Description
A major focus of our research is toward targeted drug therapy and diagnostic tools for central nervous system (CNS) diseases (e.g. Alzheimer’s disease, major depression, addiction). We design and synthesize novel ligands based on natural products and/or using the designed multiple ligand approach. For example, in the past we developed unique compound libraries targeting different nicotinic acetylcholine receptors as pharmacological tools, potential therapeutics, and for positron emission tomography (PET) and single photon emission computed tomography (SPECT).


  • Pharmacy, University of Tübingen, Germany
  • Ph.D., Pharmaceutical Chemistry, University of Tübingen, Germany
  • Postdoctoral Fellow with Edythe London, NIH/NIDA, Brain Imaging Center, Baltimore, U.S.A.
  • Habilitation, Pharmaceutical Chemistry/Medicinal Chemistry, University of Bonn, Germany

Classes and Courses

  • Medicinal Chemistry
  • Radiopharmacy

Selected Presentations and/or Publications

  • Bioorg Med Chem. 2015, 23:4375-4389
  • J Nat Prod. 2014, 77:2006-2013
  • Bioorg Med Chem. 2013, 21:7283-7308
  • J Pharmacol Exp Ther. 2013, 347:424-437
  • Toxicon. 2013, 70:170-178
  • JACC Cardiovasc Imaging. 2012, 5:528-536
  • Science. 2011, 332:1330-1332

Awards and Honors

  • Ph.D. Scholarship Award, University of Tübingen, Germany, 1992
  • Research Scholarship Award, University of Tübingen, Germany, 1994
  • Nomination for the Teaching Award, (Universities of Baden-Württemberg), Germany, 1997
  • Fogarty International Fellow (NIH/NIDA), U.S.A., 1997-1998
  • NIDA Director’s Award of Merit (Development of PET/SPECT Tracers), 1998
  • Habilitation Award, Pharmacy, University of Bonn, Germany, 2001
  • Rottendorf Award (Pharmaceutical Sciences), Germany, 2007
  • Teaching Award for Pharmaceutical Sciences (UH Hilo - DKICP), 2009 and 2011