Department of Pharmaceutical Sciences

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André S. Bachmann, Ph.D.
Andre S. Bachmann

Professor

André S. Bachmann, Professor and researcher in the Department of Pharmaceutical Sciences, studies polyamine inhibitors that affect the proliferation of cancer. His laboratory’s research is focused on providing new insights into a devastating form of pediatric cancer called neuroblastoma. Bachmann studies ornithine decarboxylase (ODC), an enzyme that often is over-expressed in cancer. He has shown that this protein promotes neuroblastoma tumor growth, while a specific suicide inhibitor of ODC called DFMO promotes cancer cell death (Oncogene, 2005). Bachmann's laboratory also studies the molecular mechanisms of proteasome-mediated cell death in neuroblastoma and discovered a new proteasome inhibitor drug class (syrbactins) in collaboration with his European colleagues (Nature, 2008). Bachmann has advanced his laboratory research with DFMO from ‘bench to bedside’ which led to ongoing phase I and phase II clinical studies with relapsed neuroblastoma patients, in collaboration with Dr. Giselle Sholler of the DeVos Children’s Hospital in Grand Rapids, MI and the Neuroblastoma and Medulloblastoma Translational Research Consortium (NMTRC).

Education

  • M.S., Microbiology (1994), University of Zurich, Switzerland
  • Ph.D., Biology (1998), University of Zurich, Switzerland
  • Postdoctoral Fellow with Karin Moelling, Molecular Oncology & Medical Virology, University of Zurich, Switzerland

Classes and Courses

  • PHPS 569 Cancer Prevention (Course Coordinator and Lecturer)
  • PHPS 703 Cancer Biology (Lecturer)
  • PHPP 517 Integrated Therapeutics III (Lecturer)
  • PHPS 509 Pathophysiology (Lecturer)
  • MBBE 699 Directed Research (Supervisor)
  • PHPS 599 Directed Studies in Pharm Sci (Supervisor)

Selected Peer-Reviewed Publications

  • Oncogene, 2005, 24(36):5606-18
  • Clinical Cancer Research, 2007, 13(21):6312-9
  • Cancer Research, 2008, 68(23):9825-31
  • Nature, 2008, 452(7188):755-8
  • Molecular Cancer Therapeutics, 2009, 8(7):2067-75
  • PNAS, 2009, 106(16):6507-12
  • International Journal of Cancer, 2010, 126(9):2012-24
  • Cancer Science, 2010, 101(7):1624-31
  • Biochemical Pharmacology, 2010, 80(2):170-8
  • Biochemistry, 2012, 51(34):6880-8
  • International Journal of Cancer, 2013, 133(6):1323-33
  • Journal of Molecular Biology, 2014, 426(2):332-46

Selected News Releases

  • Star Bulletin, Honolulu, April 27, 2008
  • Star Advertiser, Honolulu, June 26, 2010
  • Tribune Herald, Hilo, August 31, 2010
  • Tribune Herald, Hilo, March 7, 2012 (front page)

Grants

  • R01, National Cancer Institute (NCI), NIH
  • Hawaii Community Foundation (HCF)
  • Magic Water Foundation
  • Weinman Foundation

Awards and Honors

  • Swiss National Science Foundation Award, 1994
  • Siemens National Mentor Award, 2007
  • Inaugural Weinman Award for Translational Research, 2010